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How Tumor Suppressor Genes Block Cell Division

View the animation below, then complete the quiz to test your knowledge of the concept.






1The proteins ________ work together to free the transcription factor that is bound by the retinoblastoma protein.
A)p53 and p21
B)p53 and cyclin
C)cyclin and E2F
D)cyclin and cyclin dependent kinase
E)cyclin dependent kinase and p53



2Mutated forms of the Rb protein
A)bind to E2F thereby promoting uncontrolled cell division.
B)bind to E2F thereby inhibiting cell division.
C)bind to E2F but have no effect on cell division.
D)do not bind to E2F thereby inhibiting cell division.
E)do not bind to E2F thereby promoting uncontrolled cell division.



3The protein ________ checks for damaged DNA, thereby acting as a "quality control" for the cell.
A)E2F
B)cyclin dependent kinase
C)p53
D)p21
E)cyclin



4The protein p21 keeps cyclin and cyclin dependent kinase from binding to each other.
A)True
B)False



5The protein product of the tumor suppressor gene Rb acts on the G1 checkpoint.
A)True
B)False







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