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The Function of Cohesin

How are chromosomes held together? Sister chromatids are individual strands of DNA. In order for mitosis or meiosis to function properly, sister chromatids need to be attached in an organized fashion so that the two chromatids have the same orientation. The chromatids also need to be able to separate during anaphase. Initially, the chromatids need to be attached along their entire length, then later only at the centromere. Sister chromatids are attached using a protein called cohesin.

View the animation below, then complete the quiz to test your knowledge of the concept.






1Cohesin complexes
A)mediate the condensation of chromosomes.
B)promote the relaxation of chromosomes.
C)hold a chromosome’s sister chromatids together.
D)allow crossing-over between homologous chromosomes.
E)facilitate the chromosome’s binding to the nuclear membrane.



2The arms of the sister chromatids dissociate from each other during ________ of mitosis.
A)prophase
B)interphase
C)metaphase
D)anaphase
E)telophase



3The sister chromatids of a chromosome fully separate during ________ of mitosis.
A)prophase
B)interphase
C)metaphase
D)anaphase
E)telophase



4Cohesin complexes associate with the chromosomes after chromosome condensation has taken place.
A)True
B)False



5The cohesin complexes of the centromeric region are the last ones to be degraded.
A)True
B)False







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