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DNA Replication (E. coli)

Is the entire DNA molecule synthesized simultaneously? DNA exists as long strands. It is most stable in its double stranded state. Synthesis takes place one base at a time along each strand. Only a fairly small portion of the molecule is uncoiled at one time. In the uncoiled region the strands separate for DNA synthesis. Having only a small portion of the strand in its single-stranded state at any one time reduces the risk of damage to the molecule during synthesis. DNA polymerase, the enzyme that synthesizes the new strands, passes along the original strands, adding bases one at a time. The polymerase enzyme, as well as other molecules, checks for errors after the addition of new bases.

View the animation below, then complete the quiz to test your knowledge of the concept.






1Which of the following prevents supercoiling of the DNA strands ahead of the replication bubble?
A)helicase
B)topoisomerase
C)DNA binding proteins
D)DnaA
E)all of the above



2Which of the following molecules initiates the formation of the replication bubble?
A)helicase
B)DNA polymerase
C)DnaA
D)topoisomerase
E)DNA primase



3Which of the following synthesizes the daughter strands during DNA replication?
A)DNA primase
B)helicase
C)RNA polymerase
D)DNA polymerase
E)topoisomerase



4Synthesis of the daughter DNA strand from the leading strand template occurs in a 5’ to 3’ direction.
A)True
B)False



5Okazaki fragments are involved in the replication of the leading strand in a replication bubble.
A)True
B)False







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