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Holliday Model

View the animation below, then complete the quiz to test your knowledge of the concept.






1According to the Holliday model, the first step of recombination involves a nick in
A)only one DNA strand of each of the two homologous chromosomes.
B)only one DNA strand of only one of the two homologous chromosomes.
C)both DNA strands of each of the two homologous chromosomes.
D)both DNA strands of only one of the two homologous chromosomes.
E)either one or both strands of each of the two homologous chromosomes.



2Arrange the following in the proper order in which they occur during recombination.

1. Holliday junction formation
2. Strand invasion
3. Branch migration
A)1, 2, 3
B)2, 1, 3
C)2, 3, 1
D)3, 2, 1
E)3, 1, 2



3After isomerization, cleavage by an endonuclease results in
A)two nonrecombinant chromosomes, each containing a heteroduplex region.
B)two nonrecombinant chromosomes, without heteroduplex regions.
C)two recombinant chromosomes, each containing a heteroduplex region.
D)two recombinant chromosomes, without heteroduplex regions.
E)two chromosomes that are unchanged from the original chromosome.



4The Holliday junction consists of a single DNA strand containing genetic material from two different chromosomes.
A)True
B)False



5The Holliday model can be used to explain crossing over in meiosis.
A)True
B)False







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