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IgE Mediated (Type 1) Hypersensitivity (Quiz 2)

How do allergies develop? Allergies are exaggerated and inappropriate immune responses caused by B cells producing excess IgE antibodies. An allergen is a foreign substance, often food, pollen, dust (small fragments of organic material), or a chemical such as an antibiotic. The allergen binds to the antibodies and triggers a reaction that includes the production of histamine. The effect is usually local, as in hay fever, but in some cases the whole body can be affected with very serious health consequences. Histamines can cause a dramatic drop in blood pressure and lead to anaphylactic shock. The reasons for the development of allergies are unclear. It is possible that they are a side effect of evolved immune responses to eukaryotic parasites such as nematode worms. Allergies can develop at any time and can become more or less severe with age.

View the animation below, then complete the quiz to test your knowledge of the concept.

1Arrange the following events in the proper order in which they occur during an allergic response.
1 = Individual experiences symptoms
2 = Individual is sensitized to antigen
3 = IgE attaches to mast cells
4 = Antigen binds to IgE
A)1, 2, 3, 4
B)1, 3, 4, 2
C)2, 3, 1, 4
D)2, 3, 4, 1
E)2, 4, 3, 1

2A hypersensitivity reaction occurs
A)during the first exposure to an antigen.
B)during a second or subsequent exposure to an antigen.
C)in individuals with diseases of the immune system.
D)only in children.
E)only in individuals with asthma.

3The inflammation response triggers all of the following EXCEPT
A)dilation of capillaries.
B)constriction of airways.
C)inhibition of mucus.

4A plasma cell is a mature T-helper cell that produces antibodies.

5Histamine is released from mast cells.

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