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Signal Transduction by Extracellular Receptors

View the animation below, then complete the quiz to test your knowledge of the concept.






1Ion channels...
A)open when a first messenger binds to a membrane receptor protein / tyrosine kinase complex, which opens the ion channel and prompts the cell response.
B)open when a first messenger binds to a membrane receptor protein / G protein complex, which opens the ion channel and prompts the cell response.
C)open when a first messenger binds to a membrane receptor protein, which opens the ion channel and prompts the cell response.
D)open when a first messenger binds to a membrane receptor protein / JAK kinase, which opens the ion channel and prompts the cell response.
E)open when a first messenger binds to a membrane receptor protein / docking protein complex, which opens the ion channel and prompts the cell response.



2The function of a docking protein is...
A)to bind to the first messenger / receptor protein complex which activates an effector protein which initiates multiple steps leading to a cell response.
B)to bind with the JAK kinase / receptor protein / first messenger complex, which then binds to the phosphate from an ATP molecule, and initiates multiple steps leading to a cell response.
C)to bind to the first messenger / receptor protein complex which opens an ion channel and promotes the cell response.
D)to bind to a phosphate from ATP and the tyrosine kinase / receptor protein / first messenger complex to initiate multiple steps leading to a cell response.
E)to bind with a G protein which activates an effector protein which initiates multiple steps leading to a cell response.



3The function of a G protein is...
A)to bind to the first messenger / receptor protein complex which opens an ion channel and promotes the cell response.
B)to relay a signal from the first messenger / receptor protein complex to activate an effector protein in the cell membrane which leads to multiple steps which produce a cell response.
C)to bind to a phosphate from ATP and the tyrosine kinase / receptor protein / first messenger complex to initiate multiple steps leading to a cell response.
D)to generate a change in membrane potential or a second messenger system which promotes the cell response.
E)to bind with the JAK kinase, which then initiates multiple steps leading to a cell response.



4First messengers are by definition hydrophobic.
A)True
B)False



5The common thread for signal transduction by extra cellular receptors is that a first messenger is unable to pass through the cell membrane, and therefore must activate a membrane receptor protein to initiate an intracellular response.
A)True
B)False







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